If you’re an avid Twitter user, chances  are you’re using one of these Twitter Desktop Applications that  basically allow you to receive and post Tweets from your desktop.  Meaning, you don’t have to visit your Twitter.com page from time to time  to find out  what’s new about your Twitter friends. If you haven’t used  a Twitter desktop application before, well this might be the right time  to do so. We’ve picked best of the Twitter Desktop Applications  available for you to use.
Some of the Twitter clients mentioned here are based on Adobe AIR so you may use them on Linux and Mac as well. Let’s dive in.
1. Blu (Native Windows Twitter Client)
Blu  in one word is beautiful. Powered by WPF, Blu showcases your Twitter  timeline inside an animated and colorful interface. With Blu, you can  reply to your Tweets inline so you don’t lose the current view. Then you  can scroll unlimitedly so you can easily see older tweets without  having to click anything. But the best part is this – if you see a  message in your Twitter stream that is in reply to another tweet, you  can click this message to see the original tweet that started the whole  conversation. Few Drawback are it doesn’t support multiple Twitter  accounts, you cannot follow your lists in Blu, there’s no option to  search tweets yet it’s impressive.
2. Destroy Twitter
DestroyTwitter,  an Adobe AIR powered Twitter desktop client, is again very popular for  its minimalistic but innovative interface. The unique thing about  Destroy Twitter is its support for themes – you can either download ready-made themes  or use the online theme-builder to create one that matches your taste.  DestroyTwitter uses impressive transitions when switching from one  screen to another and it’s probably the only desktop client that lets  you edit your own Twitter profile. Then there’s support for Twitter  trends so that you can know what’s hot on Twitter without having to  visit the Twitter site. Destroy Twitter is lightweight and extremely  fast. You can also configure the application so that it always stays on  top of other applications.
3. DigiTweet
An open source desktop Twitter applications for Windows.  Through Windows Presentation Foundation, DigiTweet  provides Twitter functionalities with rich user interface. It’s notable  features include search facility for finding other twitter users as  well as Twitter contents, and a friends list for viewing  Twitter users  you are following and who are following you.
4. Digsby
The beloved IM, email notification, and  social networking application also does Twitter, but it’s only available  for PCs at the moment. On the social networking side, Digsby  pulls in Facebook, MySpace, Twitter, and LinkedIn so you can get a more  complete view of what’s happening across your entire social presence.
5. Mixero
AIR powered Mixero  is aimed at reducing noise and making it easier for you to keep track  of updates that could be more important to you. It offers advanced  filtering so you can hide spammers from your Twitter stream (based on  usernames or even stop-words), and lets you arrange those you follow  into groups that are integrated with Twitter lists. You can preview  images from Twitpic, Flickr, YouTube video frames, etc. directly in your  timeline. Another good feature in Mixero is “Conversations” – you can  click the bubble (speech) icon next to any tweet to find all other  previous tweets that may part of that conversation.
6. Mitter
Mitter  is a simple crossplatform Twitter client with a clean and fully  customizable interface. It supports  docking on systray. It can be  easily  integrated with GNOME desktop. Additionally, it offers a console  client.
7. PeopleBrowsr
The desktop version is just as  complicated and feature-rich as the web app (you’ll need to log in to  the website to find the download link in lower right-hand corner) only  if you can afford it (But they are giving it for Free till 4th Jan 2010  so Hurry up!). With PeopleBrowsr  you get a full-featured Twitter app that is bloated with features like  export, sort by Twitter name or number of followers, map or gallery  views, stats on stacks (which are like columns), an aggregate view of  tweets across stacks, simultaneous posting to other services, quick  access to a number of different filters, and so much more. And we  haven’t even begun to discuss the integrations with every popular social  site on the planet. Even though the light mode is a little easier, this  app is better left to extreme power users. Plus all those features seem  to really slow it down.
8. Seesmic Desktop for AIR
Seesmic Desktop  is the original Adobe AIR powered Seesmic app, and it works with  Twitter as well as Facebook (including Facebook Pages). With Seesmic  Desktop, you can mark individual tweets as spam, follow new people and  unfollow (or even block) other people from your timeline. When sharing  images on Twitter, you can either upload images from the desktop or  capture a picture right from your webcam. Although Seesmic Desktop will  run on any operating system, it uses a Mac OS style UI which doesn’t  look that good on a Windows desktop. The best part about Seesmic Desktop  is its support for Facebook Pages – you can post new messages or even  moderate comments on pages that you own.
9. Seesmic for Windows
Launched during Microsoft PDC ‘09, Seesmic for Windows  is a beautiful desktop client for Twitter with a slightly translucent  and tabbed interface. Seesmic for Windows can handle multiple Twitter  accounts – you can get a combined timeline or look at your @replies,  direct messages and sent messages for individual accounts separately.  You can post the same update /link /photo to one or more Twitter account  simultaneously. This is a native Windows application and doesn’t  require Adobe AIR.
10. SharedMinds Desktop
The interface of SharedMinds Desktop  for Windows is inspired by Outlook 2007 – you can even change themes  from Sliver to Blue as in Microsoft Office. The similarity doesn’t end  here – you navigate tweets just like you move across records in an  Access database. What’s unique about SharedMinds Desktop is the  integrated browser – if there’s a link inside a tweet, you can read the  corresponding web page directly inside the Twitter client without having  to launch a separate tab in your browser. However, you cannot share  pictures and other files with this app.
11. Snitter
This is an Adobe AIR powered Twitter client compatible for Windows. Snitter  offers auto updates tweet list, recent list of tweets, 20 most recent  items in your timeline, 20 most recent replies,  20 most recent direct  messages and more. Further, it has options for viewing and filtering the  followers.
12. Sobees for Windows
Sobees  offers a fresh interface and allows you to choose your own layout for  different social services. Sobees includes an anti-spam feature that  will let you block certain words from appearing in your Twitter stream.  You can run Sobees on any Windows computer as long as it has .NET  installed.
13. Spaz
Spaz  is an free open source Twitter client with attractive design and high  customizability. Some of its key features include directory listing of  users, built in global search, short URL creation tool, markdown syntax  support and user-defined CSS overrides. Spaz also offers multiple themes  and supports the user defined themes. Additionally, Spaz comes with  debugging and development tools.
14. TweetDeck
One of the most popular Twitter apps, TweetDeck  is great for managing all your favorite social services including  Twitter, Facebook, LinkedIn and MySpace from one place. Its multicolumn  interface not only allows you to keep up with all your social accounts  but also with Twitter lists and any custom searches that you may have  saved inside Twitter. With TweetDeck, you can see a very detailed  profile of any Twitter user, you can follow (or unfollow) users and even  put them in any of your Twitter lists. TweetDeck supports inline  translation so you can easily read foreign language tweets that may  appear in your Timeline or search results. If you work across multiple  computers, you can setup an account at TweetDeck and that will save you  from the hassle of having to configure Tweetdeck on every single  computer. And if you are no big fan of Twitter’s retweet function, you  can opt for the classic version of “retweet” (RT).
15. Tweetr
A lesser known simple app, Tweetr  is beautiful Adobe AIR based app that doesn’t support multiple  accounts, and isn’t right for power users, but might be just perfect for  lightweight Twitterers. You’re not going to get columns, groups,  search, or filters, but you can share files and take photos with your  web cam.
16. TweetyBot
This is most simplistic Twitter desktop application for Windows. TweetyBot  includes some exquisite features. It features a number of tabs with  options for tweet, replies, directs and more. In addition, this Twitter  client allows you to manage the Tweets. One of its best features is the  Alert list tab. It provides pop-up alerts when your favorite twitterers  update their status.
17. Twhirl from Seesmic
Twhirl  is a quick and easy-to-use Twitter client with a minimal yet beautiful  UI. You can even choose your own color schemes and font styles for the  UI. Unlike heavy-weights like Seesmic or TweetDeck, Twhirl doesn’t offer  loads of features but if all you need is a way to quickly post status  updates on your Twitter timeline, this could be a good choice. Twirl  also offers integration with other less-common networks such as  identi.ca and FriendFeed, and lets you cross-post updates to other  social networks via Ping.fm. Twhirl is from Seesmic, the same company  the develops previously mentioned Seesmic Desktop for AIR and Seemsmic  for Windows.
18. Twitteroo
Twitteroo  is a feature-rich Twitter client for Windows. This exclusive twitter  client provides you with Twitter notifications, URL shortening and  viewing friends timeline or public timeline. Browse to Twitter user page  or personal websites.
19. Twunami
Twunami,  a feature-rich Twitter desktop application which boasts of the  following basic functionalities – configurable Tweet workspace, optional  persistent reminders, on click Tweet/Retweet/SuperTweet/SuperRetweet,  threaded tweets, threaded DMs, mark Tweets as read/unread, sort tweets  by newest or oldest, and definitely so much features.
20. Witty
Witty  is a free open source Twitter client for Windows. It is powered by  Windows Presentation Foundation(WPF). This Twitter client allows you to  view status updates, replies, specific user’s timeline, twitter status,  response to direct messages and more. It provides the links to open the  users default browser. The new messages are highlighted with yellow fade  technique. The beta version is also available.
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